Mar Gregory Karotemprel was born on 6 May 1933 at Chemmalamattam in Kottayam district. He joined the CMI congregation and made his first profession on 8 December 1955 at Mannanam. He did his philosophical and theological studies at Dharmaram Vidya Kshethram, Bangalore. He was ordained priest on 17 May 1963. He was elected as the Provincial of the S.H. Province of the CMI congregation in 1978. While serving as the Provincial, he was appointed as the bishop of Rajkot.His consecration and installation as bishop took place on 24 April 1983.